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A review of literature referable to management issues for women with epilepsy (WWE) was undertaken for the development of practice parameter. Pregnancy outcome literature for WWE spans several decades. Methodology varies and interpretation is complicated by modern management strategies. Contributions of socioeconomic factors, AEDs, maternal epilepsy, and seizures during pregnancy to adverse pregnancy outcomes have not been clearly delineated. There is a biologic basis for recommendations concerning contraception, folate supplementation, vitamin K use in pregnancy, breast-feeding, metabolic bone disease, catamenial epilepsy, and reproductive endocrine disorders, but no outcome studies afford a strong evidence base for practice recommendation. WWE face health issues for which there is no available outcome literature to guide decision making. The urgent need for studies in many of these areas is highlighted by expanded treatment options with new AEDs and epilepsy surgery. |
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anticonvulsants
anticonvulsants,blood level determination of
anticonvulsants,teratogenicity of
anticonvulsants,untoward effects of
breast feeding
congenital birth defects
congenital malformation
developmental retardation
folic acid
menses,seizure with
obstetric neurologic injuries
oral contraceptives
outcome research
pregnancy,anticonvulsants during
pregnancy,neurologic complications in
review article
seizure
seizure,pregnancy
seizure,treatment of
seizure,women
stillbirth
teratogenesis
treatment of neurologic disorder
vitamin K
vitamin supplementation
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